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Ju Seon Lee 1 Article
Postmortem Blood and Tissue Concentration of Carisoprodol and Meprobamate
Hye Young Choi, Hwa Kyung Choi, Ju Seon Lee, Sang Hee Woo, Han Sun Lee, Yoo Sin Park, Hee Sun Chung
J Korean Soc Clin Toxicol. 2003;1(1):34-39.   Published online June 30, 2003
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Carisoprodol (CSP) is commonly prescribed as a skeletal muscle relaxant. Recently, we encountered 7 suicidal cases in which carisoprodol was detected. We developed a rugged, sensitive, and specific method for the determination of CSP and meprobamate (MPB) by GC and GC/MS. Postmortem blood concentrations of CSP and MPB ranged 22.9-124.4 ,$mu$g/ml and its metabolite, 26.8-144.5 ,$mu$g/ml respectively. Among 7 cases studied, Only CSP was ingested in 4 cases and combination of CSP and dextromethorphan was ingested in 2 cases according to the case history and one case was with ethanol. The order of the tissue concentration of CSP and MPB was liver> kidney > brain, and the concentration of MPB was higher than that of CSP in all tissues. The MPB /CSP concentration ratios of urine, bile juice, liver, kidney, brain and blood were 15.7, 4.0, 1.2, 1.4, 1.4 and 1.0 respectively. There was a big difference in concentration of CSP and MPB in 7 cases due to differences in the amount of dose administered and time to death after dosing.

JKSCT : Journal of The Korean Society of Clinical Toxicology