- A Case of Myoclonus Presenting as a Side Effect of Amitriptyline
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Jong-Pil Choi, Seong-Soo Park, Joon-Seok Park, Sang-Jun Na
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J Korean Soc Clin Toxicol. 2006;4(2):155-157. Published online December 31, 2006
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 Abstract
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- Myoclonus is manifested in a variety of situations including metabolic derangements, brain lesions, epilepsy, and drugs toxicity. We reported a rare case of amitriptyline-induced myoclonus. A 64-year-old man with a tension-type headache was administered amitriptyline at 15 mg/day. Eight days after initiation of amitriptyline, multifocal myoclonus developed, involving the face and upper extremities. Two hours after the administration of clonazepam at 1 mg, myoclonus resolved completely.
- Indoxacarb Pesticide Poisoning with Methemoglobinemia
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Jae-Hoon Shin, Jae-Kwang Lee, Seong-Soo Park, Sang-Jun Na, Joon-Seok Park
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J Korean Soc Clin Toxicol. 2006;4(2):158-160. Published online December 31, 2006
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Abstract
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- Acute methemoglobinemia is induced by various causes, especially ingestion of oxidizing agents such as phenazopyridine, dapsone, and nitrite. Indoxacarb is an oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. It is known to block voltage-gated Na+ channels in insects and mammals, but the mechanism is not yet well understood. We describe a case of a 41-year-old woman with methemoglobinemia that developed following Indoxacarb ingestion, which improved after intravenous injection of methylene blue. This is the first known such case. If signs and symptoms of methemoglobinemia occur after Indoxacarb ingestion, antidotal therapy with methylene blue should be considered as a necessary treatment.
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KSCT
Korean Society of Clinical Toxicology