Journal of The Korean Society of Clinical Toxicology

Seok Ran Yeom

2 Articles

Use of succimer as an alternative antidote in copper sulfate poisoning: A case report: Sang Kyoon Han, Sung Wook Park, Young Mo Cho, Il Jae Wang, Byung Kwan Bae, Seok Ran Yeom, Soon Chang Park; J Korean Soc Clin Toxicol. 2021;19(1):59-63. Published online June 30, 2021; DOI: https://doi.org/10.22537/jksct.2021.19.1.59

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Copper sulfate is widely used as a fungicide and pesticide. Acute copper sulfate poisoning is rare but potentially lethal in severe cases. Copper sulfate can lead to cellular damage of red blood cells, hepatocytes, and myocytes. Toxic effects include intravascular hemolysis, acute tubular necrosis and, rhabdomyolysis. A 76-year-old man presented with vomiting and epigastric pain. He had ingested a copper-containing fungicide (about 13.5 g of copper sulfate) while attempting suicide 2 hours prior to presentation. From day 3 at the hospital, laboratory findings suggesting intravascular hemolysis were noted with increased serum creatinine level. He was treated with a chelating agent, dimercaptosuccinic acid (succimer). His anemia and acute kidney injury gradually resolved with a 19-day regimen of succimer. Our case suggests that succimer can be used for copper sulfate poisoning when other chelating agents are not available.

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Acute poisoning of copper sulfate: a case report and review literature
Samaneh Hajimohammadi, Somayeh Gharibi, Vahid Pourbarkhordar, Seyed Reza Mousavi, Hanieh Salmani Izadi
The Egyptian Journal of Internal Medicine.2022;[Epub] CrossRef

CT Findings of Perforation of the Stomach after Ingestion of Glacial Acetic Acid: Hohyun Kim, Seok Ran Yeom, Hyun Min Cho, Kwang-Hee Yeo, Jae-Hun Kim; J Korean Soc Clin Toxicol. 2018;16(2):161-164. Published online December 31, 2018; DOI: https://doi.org/10.22537/jksct.2018.16.2.161

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Abstract PDF: The ingestion of corrosive substances often leads to severe morbidity and mortality. Acids produce coagulation necrosis with a lesser degree of penetration, whereas alkalis produce liquefactive necrosis with penetration. Acetic acid is a clear, colorless organic acid with a pungent, vinegar-like odor. The ingestion of highly concentrated acetic acid (glacial acetic acid) may cause a range of complications. On the other hand, perforation of the stomach is extremely rare but it has a high mortality rate. This paper reports a case of perforation of the stomach after the ingestion of glacial acetic acid with suicidal intent in an otherwise healthy 76-year-old woman.

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