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HOME > J Korean Soc Clin Toxicol > Volume 12(1); 2014 > Article
A Case of Acute Hepatic Failure due to Acetaminophen Overdose Treated with Molecular Adsorbents Recirculating System$^{(R)}$
Byung Keun Yang, Je Sung You, Young Seon Joo, Sung Phil Chung, Hahn Schick Lee
Journal of The Korean Society of Clinical Toxicology 2014;12(1):31-34
DOI: https://doi.org/
Published online: June 30, 2014
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1Department of Emergency Medicine, Yonsei University College of Medicine
2Department of Emergency Medicine, Yonsei University College of Medicine
3Department of Emergency Medicine, Yonsei University College of Medicine
4Department of Emergency Medicine, Yonsei University College of Medicine
5Department of Emergency Medicine, Yonsei University College of Medicine

We report on a patient who developed acute hepatic failure despite intravenous N-acetyl cysteine therapy who was treated with the Molecular Adsorbents Recirculating System (MARS). She presented 20 hours after the ingestion of 13 g of acetaminophen. The MARS is based on albumin dialysis principle which can be applied for patients with acute poisoning from drugs that have high protein-binding capacity because of its ability to selectively remove from circulation protein-bound toxins. The clinical toxicologist should be consider this technology when treating patients with hepatic failure following acetaminophen poisoning.

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JKSCT : Journal of The Korean Society of Clinical Toxicology