Skip Navigation
Skip to contents

JKSCT : Journal of The Korean Society of Clinical Toxicology

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Korean Soc Clin Toxicol > Volume 16(1); 2018 > Article
The Effect of Intravenous Lipid Emulsion in a Rat Model of Verapamil Toxicity
Dae-Myung Ha, Dong Hoon Kim, Taeyun Kim, Soo Hoon Lee, Jin Hee Jeong, Sang Bong Lee, Daesung Lim, Changwoo Kang
Journal of The Korean Society of Clinical Toxicology 2018;16(1):9-14
DOI: https://doi.org/10.22537/jksct.2018.16.1.9
Published online: June 30, 2018
  • 92 Views
  • 0 Download
  • 0 Crossref
  • 0 Scopus
1Department of Emergency Medicine, Gyeongsang National University School of Medicine
2Department of Emergency Medicine, Gyeongsang National University School of Medicine
3Department of Emergency Medicine, Gyeongsang National University School of Medicine
4Department of Emergency Medicine, Gyeongsang National University School of Medicine
5Department of Emergency Medicine, Gyeongsang National University School of Medicine
6Department of Emergency Medicine, Gyeongsang National University School of Medicine
7Department of Emergency Medicine, Gyeongsang National University Changwon Hospital
8Department of Emergency Medicine, Gyeongsang National University School of Medicine

Purpose: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated the hemodynamic changes and survival in a rat model of verapamil intoxication. Methods: Fourteen male Sprague-Dawley rats were sedated and treated with ILE or normal saline (control), followed by continuous intravenous infusion of verapamil (20 mg/kg/h). Mean arterial pressure and heart rate of rats were monitored during the infusion. In addition, the total dose of infused verapamil and the duration of survival were measured. Results: Survival was prolonged in the ILE group ($32.43{pm}5.8min$) relative to the control group ($24.14{pm}4.3min$) (p=0.01). The cumulative mean lethal dose of verapamil was higher in the ILE group ($4.3{pm}0.7mg/kg$) than in the control group ($3.2{pm}0.5mg/kg$; p=0.017). Conclusion: ILE pretreatment prolonged survival and increased the lethal dose in a rat model of verapamil poisoning.

Related articles

JKSCT : Journal of The Korean Society of Clinical Toxicology