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HOME > J Korean Soc Clin Toxicol > Volume 18(2); 2020 > Article
Clinical Characteristics and Risk Factors of Acute Kidney Injury in Patients with Glyphosate Poisoning
Hyung Hun Park, Kyu Ill Choi, Je Won Lee, Jung Min Park, Jinwook Park, Sang Moon Noh, Jaekyung Cho, Daero Lee, Jae Chul Cho, Dong Chan Park, Yang Hun Kim, Joo Hwan Lee
Journal of The Korean Society of Clinical Toxicology 2020;18(2):110-115
DOI: https://doi.org/10.22537/jksct.2020.18.2.110
Published online: December 31, 2020
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1Department of Emergency Medicine, Daegu Fatima Hospital
10Department of Emergency Medicine, Daegu Fatima Hospital
11Department of Emergency Medicine, Daegu Fatima Hospital
12Department of Emergency Medicine, Daegu Fatima Hospital
2Department of Emergency Medicine, Daegu Fatima Hospital
3Department of Emergency Medicine, Daegu Fatima Hospital
4Department of Emergency Medicine, Daegu Fatima Hospital
5Department of Emergency Medicine, Daegu Fatima Hospital
6Department of Emergency Medicine, Daegu Fatima Hospital
7Department of Emergency Medicine, Daegu Fatima Hospital
8Department of Emergency Medicine, Daegu Fatima Hospital
9Department of Emergency Medicine, Daegu Fatima Hospital

Purpose: Acute kidney injury (AKI) in patients with glyphosate poisoning has a poor prognosis. This study aimed to predict the risk factors for AKI in patients with glyphosate poisoning at the emergency department (ED). Methods: Clinical data on glyphosate poisoning patients at ED who were older than 18 years were collected retrospectively between January 2013 and December 2019. The clinical characteristics and clinical outcomes of the AKI group in patients with glyphosate poisoning were compared with the non-AKI (NAKI) group. Results: Of 63 glyphosate poisoning patients, AKI was observed in 15 (23.8%). The AKI patients group showed the following: old age (p=0.038), low systolic blood pressure (p=0.021), large amount of ingestion (p=0.026), delayed hospital visits (p=0.009), high white blood cells (WBC) (p<0.001), high neutrophil counts (p<0.001), high neutrophil-lymphocyte (LN) ratios (p<0.001), high serum potassium (p=0.005), low arterial blood pH (p=0.015), and low pO2 (p=0.021), low bicarbonate (p=0.009), and high Poisoning Severity Score (PSS) (p<0.001). AKI patients required hemodialysis, ventilator care (p<0.001, p=0.002), and inotropics (p<0.001). They also showed more intensive care unit admission (p<0.001), longer hospitalization (p<0.001), and high mortality (p<0.001). Logistic multivariate regression analysis showed that high WBCs (OR, 1.223) and increased LN ratios (OR, 1.414) were independently associated with the occurrence of AKI. Conclusion: In patients with glyphosate poisoning at ED, high WBCs and increased LN ratios can help predict the occurrence of AKI.

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JKSCT : Journal of The Korean Society of Clinical Toxicology