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HOME > J Korean Soc Clin Toxicol > Volume 3(1); 2005 > Article
Interaction effect of Chemical Mixtures
Jong Han Leem, Joo-Youn Shin, Yong-Kyu Kim
Journal of The Korean Society of Clinical Toxicology 2005;3(1):11-16
DOI: https://doi.org/
Published online: June 30, 2005
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1Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine
2Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine
3Department of Occupational and Environmental Medicine, Inha University Hospital, University of Inha college of Medicine

Chemical mixtures of components, each of which are present at less than guidance concentrations, may be hazardous due to additivity, interactions, or both. Toxicological interactions may increase the health hazard above what would be expected from an assessment of each component singly, or all components additively. So chemical mixture are a particular issue in public health. There are several approach to assess whether there are additivity or interaction in assessing toxicological effects, such as, components-based approach, physiologically-based pharmacokinetic /pharmacodynamic(PBPK/PD) models, hazard index method, and weight-of evidence method. If we consider interaction or additivity effects in assessing the health effects of chemcial mixtures, we can get more accurate information about toxicological effects and dose-response relationship in chemical mixtures.

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JKSCT : Journal of The Korean Society of Clinical Toxicology