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HOME > J Korean Soc Clin Toxicol > Volume 3(1); 2005 > Article
Effect of Dialysis and Perfusion on Phosphamidon in vitro
Sae Yong Hong, Hyo Wook Gil, Jong Oh Yang, Eun Young Lee
Journal of The Korean Society of Clinical Toxicology 2005;3(1):17-21
DOI: https://doi.org/
Published online: June 30, 2005
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1Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital
2Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital
3Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital
4Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital

Purfose: This study was to observe the phosphamidon reduction rate after haemoperfusion (HP) and Hemodialysis (HD) in vitro. Methods: We started off by measuring the clearance of HD and HP for the phosphamidon in vitro. Phosphamidon was measured hourly by High-pressure liquid chromatography. Results: Phosphamidon clearance was effectiveness in HP and HD. Phosphamidon reduction rate was no difference between HD and HP; $64\%$ versus $91.\%1$ at starting, $82.2\%$ versus $80.2\%$ at 1 hours, $82.2\%$ versus $73.8\%$ at 2 hours, $34.4\%$ versus $14.0\%$ at 3 hours, $14.1\%$ versus $27.4\%$ at 4 hours, $0\%$ versus $3.3\%$ at 5 hours. Conculsion: Extracorporeal elimination of phosphamidon is effective by hemoperfusio and hemodialysis in vitro. We suggest hemoperfusion may be effective in organophsphate intoxication patients.

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JKSCT : Journal of The Korean Society of Clinical Toxicology